
Main Outcomes and Measures Incident dementia (fatal and nonfatal), obtained through linkage with inpatient hospitalization or primary care records or recorded as the underlying or contributory cause of death in death registers. Registry-based dementia was ascertained through October 2021.Įxposures Accelerometer-derived daily step count, incidental steps (less than 40 steps per minute), purposeful steps (40 steps per minute or more), and peak 30-minute cadence (ie, mean steps per minute recorded for the 30 highest, not necessarily consecutive, minutes in a day). A total of 78 430 of 103 684 eligible adults aged 40 to 79 years with valid wrist accelerometer data were included. Objective To examine the dose-response association between daily step count and intensity and incidence of all-cause dementia among adults in the UK.ĭesign, Setting, and Participants UK Biobank prospective population-based cohort study (February 2013 to December 2015) with 6.9 years of follow-up (data analysis conducted May 2022). However, the association of step count and intensity with dementia incidence is unknown. Importance Step-based recommendations may be appropriate for dementia-prevention guidelines. Shared Decision Making and Communication.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience.
Challenges in Clinical Electrocardiography. Dose-response associations were assessed with restricted cubic splines with knots at 10th, 50th, and 90th centiles of the distribution of the exposure of interest. Total steps per day indicates the mean number of steps accumulated in a day incidental steps, the total daily steps at 1-39 steps per minute purposeful steps, the total daily steps at ≥40 steps per minute peak 30-minute cadence, the mean steps per minute recorded for the 30 highest, not necessarily consecutive, minutes in a day. For peak 30-minute steps, models were additionally adjusted for total steps per day. For incidental steps, models were further adjusted for purposeful steps (and vice versa). ball, arrow, pedestrian, etc.) used in the District and include as a minimum Luminous Intensity and Chromaticity tests.Īpplications addressing physics studies and pre-conceptual R&D directed towards specific future Intensity Frontier experiments are also accepted.Shading indicates 95% CIs solid lines, hazard ratios, in logarithmic scale, adjusted for age, sex, race, education, Townsend deprivation index, smoking, alcohol use, fruit and vegetable consumption, family history of cardiovascular disease and cancer, medication use (cholesterol, insulin, and hypertension), accelerometer-measured sleep, and days wearing accelerometer. Independent testing must include a minimum of two (2) randomly selected modules of each type of module (i.e. Grantor retains the right to maintain, renew, and replace all agreements memorializing the Express Third Party Uses ("Third Party Use Agreements") and to engage in all activities reasonably required to comply with Grantor’s obligations with respect to the Express Third Party Uses, subject to the following conditions: 9.1.1 Increases in Intensity or Expansion of Location or Size or Change in Use.
Intensity of development standards refer to those requirements used to define the relationship between the permitted extent, form and location of development of a lot, to the size, shape and configuration of the lot on which it is situated (e.g., floor area ratio, building coverage, building height, yard setbacks, number of stories). TYPE B HIGH INTENSITY WARNING LIGHTS (D-6-0307) All references in the plans to Type B High Intensity Warning Lights shall be considered void.